Cracked Dry Skin on the Feet and Heels?
Researchers have found that a compounded 40% urea cream hydrates the skin and improves the absorption of the antifungal medication in patients suffering from moccasin tinea pedis. In a small study, after 2 to 3 weeks, a 100% cure rate was achieved in all 12 patients treated with topical 40% urea cream and antifungal cream.
Cutis. 2004 May;73(5):355-7.
Topical Therapy for Nail Infections
A recent large prospective study has shown that onychomycosis is among the most significant predictors of foot ulcer. If left untreated, toenails can become thick, causing pressure and irritation, and thus act as a trigger for more severe complications. In the treatment of onychomycosis, compliance and drug interactions are important considerations, as diabetic patients frequently take concomitant medications.
Am J Clin Dermatol. 2009;10(4):211-20.
J Dermatolog Treat. 2005 Feb;16(1):52-5.
Studies have shown that antifungal agents can be of benefit in treating onychomycosis in patient populations that include the elderly, children, and immunocompromised individuals (e.g., transplant patients, Down's patients, HIV patients, and diabetics). The treatment modality in special patient populations should take into account the clinical presentation of onychomycosis, causative organism, patient and physician preference, concomitant medications that the patient is taking, and the potential for adverse events associated with antifungal therapy.
J Cutan Med Surg. 2004 Jan-Feb;8(1):25-30. Epub 2004 Jan 23.
Chemical nail destruction with a combination of urea and bifonazole, followed by treatment with an antifungal ointment, can be used when the nail is markedly thickened. Non-comparative trials have shown cure rates close to 70% at three months when the matrix is not involved, and 40% with matrix involvement.
Prescrire Int. 2009 Feb;18(99):26-30.
Fungal infections of the feet are commonly associated with dry, cracked skin surrounding the plantar surface and heel fissures. Hyperkeratosis can have various etiologies, and chronic conditions are often quite difficult to treat. Moccasin tinea pedis is typically resistant to topical antifungal therapy when used as sole therapy, because the scale on the plantar surface of the foot impedes or limits the absorption of the antifungal agent. However, one study showed a 100% cure rate was achieved in 12 patients with confirmed moccasin tinea pedis who were treated with topical 40% urea cream and antifungal cream concomitantly for 2 to 3 weeks.
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