The primary objective of a current multicenter, randomized controlled trial conducted by the Department of Health Sciences, University of York, UK is to compare the clinical effectiveness of two common treatments for verrucae: cryotherapy using liquid nitrogen versus salicylic acid. The primary outcome is complete clearance of all verrucae as observed on digital photographs taken at 12 weeks.
The EVERT (effective verruca treatments) trial protocol: a randomised controlled trial to evaluate cryotherapy versus salicylic acid for the treatment of verrucae
A medical record review was conducted by the Podiatry Division, Department of Orthopedics, Cabrini Medical Center, New York, NY to determine the clinical outcome and average time to resolution of verruca plantaris (plantar warts) in 20 patients treated with twice-daily applications of topical fluorouracil (5-FU) combined with topical 17% and 40% salicylic acid. Twice-daily application of topical fluorouracil and salicylic acid is a safe and effective treatment for verruca plantaris.
J Am Podiatr Med Assoc. 2005 Jul-Aug;95(4):366-9.
Because of cantharidin's potential for toxicity, the FDA has proposed that cantharidin should be limited to "topical use in the professional office setting only." Severe blistering can result from improper use, and ingestion, especially by children, can be fatal. Treatment of mucous membranes is contraindicated and placement of cantharidin near the eyes and eyelids should be avoided to prevent scleral erosion.
Caution: The treatment of plantar warts with cantharidin is NOT recommended and may have a higher rate of significant complications including lymphangitis and refractory lymphedema.
Arch Dermatol. 2001;137:1357-1360
J Am Acad Dermatol. 2000;43:503-507
Warts are a common pediatric skin infection and clearance may be enhanced by contact sensitizers, such as squaric acid dibutylester (SADBE). Contact immunotherapy with SADBE is relatively safe and an effective alternative in the management of multiple and resistant cutaneous warts in children.
J Am Acad Dermatol. 2000 May;42(5 Pt 1):803-8
Pediatr Dermatol. 2000 Jul-Aug;17(4):315-8
J Am Acad Dermatol. 1999 Oct;41(4):595-9
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