To avoid the risks of COX-2 inhibitors, our pharmacy can compound topically applied NSAIDs such as ibuprofen and ketoprofen. Topical NSAIDs have a safety profile which is superior to oral formulations. Topical NSAID administration offers the advantage of local, enhanced delivery to painful sites with a reduced incidence of systemic adverse effects.
Topical preparations can be customized to contain a combination of medications to meet the specific needs of each patient.
Topical NSAIDs for Acute Pain
BMJ. 1995 Jul 1;311(6996):22-6
The following article concludes: “Topical non-steroidal anti-inflammatory drugs are effective in relieving pain in acute and chronic conditions.”
BMJ. 1998 Jan 31;316(7128):333-8
Pharm Res. 1996 Jan;13(1):168-72
Findings of this study demonstrate that "following topical application in a patch, ketoprofen shows rapid and sustained delivery to the underlying tissues without a significant increase of the plasma drug concentration."
AAPS PharmSciTech. 2010 Mar;11(1):154-8. Epub 2010 Jan 20.
Minerva Cardioangiol. 2008 Oct;56(5 Suppl):47-53.
Topical NSAIDs have a safety profile which is superior to oral formulations. Topical NSAID administration offers the advantage of local, enhanced delivery to painful sites with higher tissue levels beneath the site of application and a reduced incidence of systemic (such as gastrointestinal) adverse effects.
Advanced Studies in Medicine, Johns Hopkins University, Volume 3 (7A), July 2003
Cochrane Database Syst Rev. 2010 Jun 16; 6: CD007402.
- Hormone Replacement Therapy for Men
- Hormone Replacement Therapy for Women
- Athlete’s Foot
- Chemical Peels
- Diaper Rash/Incontinence
- Head Lice and Scabies
- Molluscum Contagiosum
- Nail Infection/Removal
- Pigmentation Abnormalities
- Plantar Warts/Warts
- Scarring and Keloids
- Topical Anesthetics
- Sun Protection/Photoaged Skin/Wrinkles
- Examples of Compounded Medications
- Pain Management
- Palliative Care
- Sports Medicine
- Veterinary Compounding
- Wound Care
- PHYSICIANS ONLY
- SCHOLARSHIP INFO